Effect of resveratrol on sirtuins expression and cardiac complications in diabetes.

摘要: Sirtuins are the protein deacetylases, which linked to metabolic diseases and aging. There seven sirtuins present in cell, whose regulation diabetic heart is yet be explored. Resveratrol a well-known activator of SIRT-1, but its effect on other not clear. In study, we focused find out expression all with resveratrol administration them. We have induced T1DM rat model using steptozotocin T2DM by feeding high fructose diet for period eight weeks analyzed myocardial changes. was administrated both models simultaneously. Increased oxidative stress cardiac phenotype alterations shows induction abnormalities models. observed decreased SIRT-1 increased SIRT-3 activity heart. Moreover, case T1DM, gene down, except SIRT-2 levels were increased. Administration prevented alteration 2, 3 SIRT-5 Altered level acetylation corresponding changes sirtuins. conclusion, perturbed types can considered as druggable target therapeutic intervention.