Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis
作者： G K Reid , S Kargman , P J Vickers , J A Mancini , C Léveillé
DOI: 10.1016/S0021-9258(17)45446-9
关键词:
摘要: Previous studies involving transfection of cDNAs for 5-lipoxygenase-activating protein (FLAP) and 5-lipoxygenase into osteosarcoma cells have shown that both these proteins are essential leukotriene synthesis (Dixon, R. A. F., Diehl, E., Opas, Rands, Vickers, P. J., Evans, J. Gillard, W., Miller, D. K. (1990) Nature 343, 282-284). In the present study we show FLAP is in a variety known to produce leukotrienes, but absent from number which do not synthesize leukotrienes. Furthermore, differentiation human promyelocytic HL-60 cell line towards granulocytic following exposure dimethylsulfoxide associated with concurrent induction an increased capacity Cellular this system functionally dependent on as by its inhibition biosynthesis inhibitor MK-886, compound specifically binds FLAP.
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