GP and Patient Perspectives on Treatment with Non-steroidal Anti-inflammatory Drugs for the Treatment of Pain in Osteoarthritis

摘要: Two nationwide surveys were carried out using an electronic poll of 2,000 GPs and postal questionnaires sent to 30,000 patients with osteoarthritis (OA). Both found a high level gastro-intestinal (GI) side-effects in treated non-steroidal anti-inflammatory drugs (NSAIDs). Almost every GP (97%) reported experience suffering GI symptoms while on NSAID, 38% who had been hospitalised 4% died owing NSAID-induced side-effects. Most (92%) said they concerned about safety when prescribing NSAID almost third (32%) litigation from experienced bleed. Use NSAIDs OA remained high, 44% conventional at least three quarters their patients, 57% simple analgesia just 12% cyclo-oxygenase-2 (COX-2) selective inhibitor over 74% patients. Some 45% receiving compared 43% COX-2 inhibitors. (69%) stated that main therapeutic objective treat was control pain without quarter (24%) used low-dose the hope this would Dissatisfaction treatment most common reason by for re-present, 73% citing either breakthrough or incomplete relief as patient dissatisfaction. This mirrored patients' perception, 63% inadequate dissatisfaction current painkillers 17% cited stomach upsets irritation. Patient appear be united concern risks treatment. In light recent data efficacy, profile cost-effectiveness inhibitors, should re-examine medical management OA.