Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma.
作者： Nidhi Jariwala , Devaraja Rajasekaran , Rachel G. Mendoza , Xue-Ning Shen , Ayesha Siddiq
DOI: 10.1158/0008-5472.CAN-17-0298
关键词:
摘要: SND1, a subunit of the miRNA regulatory complex RISC, has been implicated as an oncogene in hepatocellular carcinoma (HCC). In this study, we show that hepatocyte-specific SND1 transgenic mice (Alb/SND1 mice) develop spontaneous HCC with partial penetrance and exhibit more highly aggressive induced by chemical carcinogenesis. Livers from Alb/SND1 exhibited relative increase inflammatory markers spheroid-generating tumor-initiating cells (TIC). Mechanistic investigations defined roles for Akt NF-κB signaling pathways promoting TIC formation mice. human xenograft models subcutaneous or orthotopic HCC, administration selective inhibitor 3', 5'-deoxythymidine bisphosphate (pdTp), inhibited tumor without effects on body weight liver function. Our work establishes oncogenic role highlights pdTp candidate therapeutic lead to treat advanced HCC. Cancer Res; 77(12); 3306-16. ©2017 AACR.
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