Updates on NSAIDs in patients with and without coronary artery disease: pitfalls, interactions and cardiovascular outcomes.

摘要: NSAIDs are used worldwide by more than 30 million people everyday, given their anti-inflammatory, analgesic and antipyretic effects. approved for several common adult diseases, including acute chronic musculoskeletal or inflammatory disease, osteoarthritis, rheumatoid arthritis other arthritic conditions, as well children with juvenile idiopathic arthritis. Importantly, the population commonly taking is that of older individuals who also represent highest risk cardiovascular (CV) gastrointestinal adverse In recent years, a growing body evidence regarding potential risks from use has emerged. The aim this review to update available data concerning in patients without CV disease analyzing mechanisms action, interference specific established protective role low-dose aspirin, increased myocardial infarction, stroke, hypertension, heart failure atrial fibrillation.