Invasion as target for therapy of glioblastoma multiforme

摘要: The survival of cancer patients suffering from glioblastoma multiforme is limited to just a few months even after treatment with the most advanced techniques. indefinable borders cell infiltration into surrounding healthy tissue prevent complete surgical removal. In addition, genetic mutations, epigenetic modifications and microenvironmental heterogeneity cause resistance radio- chemotherapy altogether resulting in hardly overcome therapeutic scenario. Therefore, development efficient strategies combat these tumors requires better knowledge proteomic alterations as well infiltrative behavior cells how this can be targeted. Among many surface receptors, members integrin family are known regulate invasion concert extracellular matrix degrading proteases. While preclinical early clinical trials suggested specific targeting promising approach, failed deliver improved cure rates up now. Little about motility, but switches modes adaption cues consequence may maintain tumor therapy. Thus, understanding molecular basis protease function for context radiochemotherapy pressing issue beneficial design approaches. This review article summarizes latest findings on integrins adds some perspective thoughts might exploited optimized multimodal therapy