Effect of Concomitant Radiochemotherapy on Invasion Potential of Glioblastoma.

摘要: Glioblastoma (GBM) is the most common primary brain tumor in adults with inevitable recurrence after oncotherapy. The insufficient effect of "gold standard" temozolomide-based concomitant radiochemotherapy may be due to inability prevent cell invasion. Peritumoral infiltration depends mainly on interaction between extracellular matrix (ECM) components and membrane receptors. Changes invasive behaviour oncotherapy can evaluated at molecular level by determining RNA expression protein levels invasion-related ECM components. nineteen molecules was determined both thirty-one GBM samples. Fifteen samples originated from first surgical procedure patients before oncotherapy, sixteen were collected second surgery local chemoirradiation. expressions measured qRT-PCR, quantitative analysis Western blots. Only MMP-9 transcript reduced (p < 0.05) whereas level, eight showed changes concordant significant decrease brevican only. results suggest that does not have sufficient impact glioblastoma, significantly affect its behavior. To avoid spread tumors into parenchyma, supplementation antiproliferative treatment anti-invasive agents worth consideration for glioblastoma.