Role of ascorbic acid in counteracting ferric nitrilotriacetate-induced nephrotoxicity in rats.
作者： S. Ansar , M. Iqbal
DOI: 10.3109/13880209.2013.802811
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摘要: AbstractContext: Ascorbic acid (AA) is a naturally occurring organic compound with antioxidant properties. It necessary for normal growth and development, has been shown to protect against tissue toxicity oxidative stress.Objective: The protective effect of AA nephrotoxicity induced in albino rats by ferric nitrilotriacetate (Fe-NTA) was evaluated.Materials methods: Male Wistar strain (4–6 weeks old) weighing 125–150 g were used this study. Animals given single dose Fe-NTA (9 mg/kg body weight, intraperitoneal) after week treatment (1 2 mg/animal/day).Results: enhanced microsomal lipid peroxidation (LPO) hydrogen peroxide (H2O2) generation 1.7- 2.2-fold, glutathione (GSH) levels decreased two-fold the activities GSH metabolizing enzymes range 2.2- 2.5-fold renal tissue. These changes reversed significantly animals receiving pretreatment AA. Treatment with...
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