Development and validation of empirical indices to assess the insulinaemic potential of diet and lifestyle.

摘要: The glycaemic and insulin indices assess postprandial response to foods, respectively, which may not reflect the long-term effects of diet on response. We developed evaluated validity four empirical insulinaemic potential usual diets lifestyles, using dietary, lifestyle biomarker data from Nurses' Health Study (NHS, n 5812 for hyperinsulinaemia, 3929 resistance). were as follows: dietary index hyperinsulinaemia (EDIH) (ELIH); resistance (EDIR) (ELIR). entered thirty-nine FFQ-derived food groups in stepwise linear regression models, defined patterns most predictive fasting plasma C-peptide, pathway (EDIH ELIH), theTAG:HDL-cholesterol ratio, insulin-resistance (EDIR ELIR). two independent samples NHS-II Professionals Follow-up (HPFS) multivariable-adjusted analyses calculate relative concentrations biomarkers. EDIH is comprised eighteen groups; thirteen positively associated with C-peptide five inversely associated. EDIR ten TAG:HDL-cholesterol eight Lifestyle had fewer components, included BMI physical activity components. In validation samples, all significantly predicted - example, corresponding biomarkers comparing extreme quintiles HPFS EDIH, 1·29 (95 % CI 1·22, 1·37); ELIH, 1·78 1·68, 1·88); EDIR, 1·44 1·34, 1·55); ELIR, 2·03 1·89, 2·19); P trend<0·0001. robust associations these novel hypothesis-driven suggest their usefulness assessing ability whole lifestyles stimulate and/or sustain secretion.