Engineering In Situ Cross-Linkable and Neurocompatible Hydrogels
作者： Xiaowei Li , Xiaoyan Liu , Ning Zhang , Xuejun Wen
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摘要: Abstract Physical injuries of the central nervous system (CNS) are prevalent and very severe because CNS has limited capacity to replace neuronal loss from injury. A growing body evidence suggested that exogenous cell transplantation is one promising strategy promote regeneration. Direct injection neural stem cells (NSCs) lesion site, however, may not be an optimal therapeutic poor viability functionality transplanted resulting local hostile tissue environment. The overall objective this study engineer injectable biocompatible hydrogel as a supportive niche provide regeneration permissive microenvironment for NSCs survive, functionally differentiate, integrate with host tissues highly hydrogel, based on thiol functionalized hyaluronic acid gelatin (Gtn-SH), which can cross-linked by poly(ethylene glycol) diacrylate (PEGD...
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