Completely resected non-small cell lung cancer: reconsidering prognostic value and significance of N2 metastases.
作者： Marc Riquet , Patrick Bagan , Françoise Le Pimpec Barthes , Eugeniu Banu , Florian Scotte
DOI: 10.1016/J.ATHORACSUR.2007.07.015
关键词:
摘要: Background Non-small cell lung cancer (NSCLC) mediastinal (N2) metastases are indicators of poor prognosis. Survival rates decrease with increasing number N2 stations and involved lymph nodes as well node size capsular invasion. Our purpose was to elucidate the impact node–related variables on outcome after surgical resection. Methods We reviewed data 2344 NSCLC patients who underwent curative resections lymphadenectomy, 586 (25%) had metastases. studied overall survival according some important covariates. Results Metastases single in 386 (66%) two or more 200 (34%). not related histology pathologic tumor (pT), but better when only one station (5-year 28.5% [median, 24 months] versus 17.2% 14 respectively; p = 0.0002. For stations, rupture, number, were significant prognostic factors. When analyzed (micrometastases, 53; nonbulky, 207; bulky metastases, 126), differences between nonbulky significant: 5-year 34% (median, 28 months) 23% 23 months), respectively ( 0.026). Presence micrometastases associated a prognosis: 21.4% months). Conclusions Prognosis for metastatic enlarged. However, presence does seems outcome.
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