Survival of Patients With Resected N2 Non–Small-Cell Lung Cancer: Evidence for a Subclassification and Implications

摘要: PURPOSE: Patients who suffer from non–small-cell lung cancer (NSCLC) with ipsilateral mediastinal lymph node involvement (N2) belong to a heterogeneous subgroup of patients. We analyzed the prognosis patients resected N2 NSCLC propose homogeneous patient subgroups. PATIENTS AND METHODS: The present study comprised 702 consecutive six French centers underwent surgical resection NSCLC. Initially, two groups were defined: clinical (cN2) and those minimal (mN2) disease in whom was not detected preoperatively at computed tomographic scan, respectively. RESULTS: median duration follow-up 52 months (range, 18 120 months). A multivariate analysis using Cox regression identified four negative prognostic factors, namely, cN2 status (P < .0001), multiple levels (L2+; P pT3 T4 stage no preoperative chemotherapy .01). For treated wi...