Preoperative chemotherapy followed by concurrent chemoradiation therapy based on hyperfractionated accelerated radiotherapy and definitive surgery in locally advanced non-small-cell lung cancer: mature results of a phase II trial.
作者： W Eberhardt , H Wilke , G Stamatis , M Stuschke , A Harstrick
DOI: 10.1200/JCO.1998.16.2.622
关键词:
摘要: PURPOSETo evaluate the feasibility and efficacy of an intensive multimodality approach with combination chemotherapy, hyperfractionated accelerated chemoradiotherapy, definitive surgery in prognostically unfavorable subgroups locally advanced non-small-cell lung cancer stages IIIA IIIB (LAD-NSCLC).PATIENTS AND METHODSFollowing staging, including mediastinoscopy, 94 patients inoperable LAD-NSCLC were treated preoperatively chemotherapy (three courses split-dose cisplatin etoposide [PE]) followed by concurrent chemoradiotherapy (one course PE combined 45 Gy radiotherapy). After repeat underwent 4 weeks postradiation.RESULTSOf consecutive (52 stage [> or = two lymph node levels involved] 42 [no pleural effusion, no supraclavicular nodes]), 62 (66%) completed induction surgery. Complete resection (R0) was achieved 50 (53% all patients) pathologic complete ...
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