Nichtkleinzelliges Lungenkarzinom im Stadium III
作者： M. Stuschke , R. M. Huber , M. Flentje , C. Rübe
DOI: 10.1007/S00761-006-1099-2
关键词:
摘要: Eine definitive Radiochemotherapie ist Standardtherapie fur Patienten mit einem prognostisch nichtoperablen, lokal fortgeschrittenen, nichtkleinzelligen Lungenkarzinom. Zwei bis 4 Kurse einer cisplatinbasierten Chemotherapie sind in Kombination definitiven thorakalen Strahlentherapie beim nichtoperablen Lungenkarzinom im Stadium IIIA/IIIB indiziert, falls keine Kontraindikation gegen die Durchfuhrung besteht. Die Evidenz aus randomisierten Studien weist darauf hin, dass – oder bei mehr als zwei Zyklen eine Komponente der simultan zur appliziert werden sollte. Drittgenerationkombinationen zeigen Unterschiede ihren Toxizitatsspektren, einige Kombinationen sehr gunstig sind.
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K. S. Albain, R. S. Swann, V. R. Rusch, A. T. Turrisi, F. A. Shepherd, C. J. Smith, D. R. Gandara, D. H. Johnson, M. R. Green, R. C. Miller, Phase III study of concurrent chemotherapy and radiotherapy (CT/RT) vs CT/RT followed by surgical resection for stage IIIA(pN2) non-small cell lung cancer (NSCLC): Outcomes update of North American Intergroup 0139 (RTOG 9309) Journal of Clinical Oncology. ,vol. 23, pp. 7014- 7014 ,(2005) , 10.1200/JCO.2005.23.16_SUPPL.7014
W Eberhardt, H Wilke, G Stamatis, M Stuschke, A Harstrick, H Menker, B Krause, M R Müeller, M Stahl, M Flasshove, V Budach, D Greschuchna, N Konietzko, H Sack, S Seeber, Preoperative chemotherapy followed by concurrent chemoradiation therapy based on hyperfractionated accelerated radiotherapy and definitive surgery in locally advanced non-small-cell lung cancer: mature results of a phase II trial. Journal of Clinical Oncology. ,vol. 16, pp. 622- 634 ,(1998) , 10.1200/JCO.1998.16.2.622
B Jeremic, Y Shibamoto, L Acimovic, L Djuric, Randomized trial of hyperfractionated radiation therapy with or without concurrent chemotherapy for stage III non-small-cell lung cancer. Journal of Clinical Oncology. ,vol. 13, pp. 452- 458 ,(1995) , 10.1200/JCO.1995.13.2.452
Noelle O'Rourke, Marta Roqué i Figuls, Nuria Farré Bernadó, Fergus Macbeth, Concurrent chemoradiotherapy in non-small cell lung cancer. Cochrane Database of Systematic Reviews. ,(2010) , 10.1002/14651858.CD002140.PUB3
B Jeremic, Y Shibamoto, L Acimovic, S Milisavljevic, Hyperfractionated Radiation Therapy With or Without Concurrent Low-Dose Daily Carboplatin/Etoposide for Stage III Non-Small-Cell Lung Cancer: A Randomized Study Journal of Clinical Oncology. ,vol. 14, pp. 1065- 1070 ,(1996) , 10.1200/JCO.1996.14.4.1065
Kiyoyuki Furuse, Masahiro Fukuoka, Masaaki Kawahara, Hideki Nishikawa, Yoshiki Takada, Shinzoh Kudoh, Nobuyuki Katagami, Yutaka Ariyoshi, Phase III Study of Concurrent Versus Sequential Thoracic Radiotherapy in Combination With Mitomycin, Vindesine, and Cisplatin in Unresectable Stage III Non–Small-Cell Lung Cancer Journal of Clinical Oncology. ,vol. 17, pp. 2692- 2692 ,(1999) , 10.1200/JCO.1999.17.9.2692
Hiroshi Onishi, Tsutomu Araki, Hiroki Shirato, Yasushi Nagata, Masahiro Hiraoka, Kotaro Gomi, Takashi Yamashita, Yuzuru Niibe, Katsuyuki Karasawa, Kazushige Hayakawa, Yoshihiro Takai, Tomoki Kimura, Yutaka Hirokawa, Atsuya Takeda, Atsushi Ouchi, Masato Hareyama, Masaki Kokubo, Ryusuke Hara, Jun Itami, Kazunari Yamada, Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional study. Cancer. ,vol. 101, pp. 1623- 1631 ,(2004) , 10.1002/CNCR.20539
Daniel T. Chang, Robert A. Zlotecki, Kenneth R. Olivier, Re-examining the role of elective nodal irradiation: finding ways to maximize the therapeutic ratio. American Journal of Clinical Oncology. ,vol. 28, pp. 597- 602 ,(2005) , 10.1097/01.COC.0000187927.06051.EC
José S.A Belderbos, Katrien De Jaeger, Wilma D Heemsbergen, Yvette Seppenwoolde, Paul Baas, Liesbeth J Boersma, Joos V Lebesque, First results of a phase I/II dose escalation trial in non-small cell lung cancer using three-dimensional conformal radiotherapy Radiotherapy and Oncology. ,vol. 66, pp. 119- 126 ,(2003) , 10.1016/S0167-8140(02)00377-8
Yasushi Nagata, Kenji Takayama, Yukinori Matsuo, Yoshiki Norihisa, Takashi Mizowaki, Takashi Sakamoto, Masato Sakamoto, Michihide Mitsumori, Keiko Shibuya, Norio Araki, Shinsuke Yano, Masahiro Hiraoka, Clinical outcomes of a phase I/II study of 48 Gy of stereotactic body radiotherapy in 4 fractions for primary lung cancer using a stereotactic body frame International Journal of Radiation Oncology Biology Physics. ,vol. 63, pp. 1427- 1431 ,(2005) , 10.1016/J.IJROBP.2005.05.034