Relevance of Pituitary Gland Magnetic Resonance Imaging Results with Clinical and Laboratory Findings in Growth Hormone Deficiency

摘要: BACKGROUND The present study investigated the relationship between detection of organic pathologies with magnetic resonance imaging pituitary gland, clinical and laboratory findings, treatment response. MATERIAL AND METHODS included a total 183 patients who had isolated growth hormone deficiency, received at least 1 year treatment, returned regularly for follow-ups, whose images were available. divided into 2 groups: those without pathological evidence imaging. Clinical features responses compared RESULTS Of patients, 105 females 78 males, 114 (62.2%) prepubertal 69 (37.8%) pubertal. Their mean age was 10.01±3.25 years (1-17.6 years). Pituitary 153 (83.6%) normal. detected (16.4%), 19 (10,4%) hypoplasia, 5 (2.7%) partial empty sella, 3 (1.7%) ectopic neurohypophysis pineal, arachnoid cyst. A statistically significant increase observed in height rate after to before both groups (p<0.001). However, group pathology (p=0. 007) post-treatment rate. Although there lower L-DOPA clonidine peak GH response, not any difference (p=0.051, p=0.113). gland length also shorter (P<0.001). CONCLUSIONS Magnetic is useful tool assessing deficiency pathogenesis predicting