Carboxylic ester hydrolase. A sensitive serum marker and indicator of severity of acute pancreatitis.

摘要: When using clinical criteria, both falsely positive and negative diagnoses of acute pancreatitis (AP) are often made. Based on a study, elevated serum levels the pancreatic lipolytic enzyme carboxylic ester hydrolase (CEH) was recently suggested to be highly specific marker pancreatitis. To determine sensitivity test for AP, study patients with diagnosis set objectively necessary. In present AP diagnosed by contrast-enhanced computed tomography in 64 patients, histopathological examination tissue removed at laparotomy 18 them. By these 42 suffered from interstitial (AIP), 22 necrotizing (NP). CEH concentrations first sample obtained each patient, 98%. From second day after admission, NP were significantly higher than AIP. Furthermore, NP, values remained raised level following 10 d, whereas significant decrease noted contrast, total amylase activities suffering AIP during observation period. We conclude, that is very high AP. remaining suggestive diminishing