Genomic organization of the UGT2b gene cluster on human chromosome 4q13.

摘要: The UDP-glucuronosyltransferases (UGTs) comprise a large family of proteins capable detoxifying wide variety both endogenous and exogenous substrates. primary function this gene superfamily is to catalyze the glycosylation substrates such as biogenic amines, steroids, bile acids, phenolic compounds various other pharmacologically relevant compounds, including numerous carcinogens, toxic environmental pollutants prescription drugs. This conjugation increases solubility these allowing them be excreted more readily through hepatic or renal mechanisms. paper describes genomic characterization chromosomal localization three UGT2B genes which together part cluster related sequences, pseudogenes found on human chromosome 4q13. A map spanning approximately 500-1000 kb region reveals presence previously described genes, at least two uncharacterized significant number remnant fragments places UGT2B4 between UGT2B7 UGT2B15. Additionally, access reference DNA bank allowed us calculate allele frequencies for SNPs: D85R in UGT2B15 Q458D amongst 803 unrelated individuals representing five ethnic populations. data presented here suggest recent evolutionary history duplication, mutation rearrangement. Furthermore, they that re-evaluation current description with respect specific degree allelic diversity molecular evolution may necessary.