Differential effect of anti-HLA class I monoclonal antibodies on resting and in vivo-induced B lymphocytes

摘要: The role of HLA class I antigens in B cell triggering was investigated by analyzing the effect monoclonal antibodies (MAbs) directed to such molecules on vitro function resting and vivo-induced lymphoblastoid (LB) cells. Staphylococcus aureus Cowan (SAC)-induced proliferation high-density lymphocytes markedly inhibited W6/32 MAb (reactive with a monomorphic determinant contributed an alpha-chain beta 2-microglobulin) but not FG2/2 2-microglobulin). inhibition due either toxic or change response kinetics. In contrast, LB cells' spontaneous DNA synthesis IgG production altered MAb, although these cells possessed surface antigens. These findings suggest that are involved activation process mature lymphocytes.