Invasive micropapillary carcinoma of the breast metastatic to the urinary bladder and endometrium: diagnostic pitfalls and review of the literature of tumors with micropapillary features.

摘要: Carcinomas with micropapillary features have been described in the breast, urinary bladder, lung, and ovary. They are characterized by presence of tufts clear spaces. Unequivocal vascular invasion is usually present at periphery tumor. Consequently, these tumors a high propensity for lymph node metastases high-stage disease. The metastatic carcinoma can consist exclusively component, which may elicit an erroneous diagnosis if located bladder or as patient presented herein. We case 59-year-old woman history bilateral breast status post-bilateral mastectomy, chemotherapy, tamoxifen therapy. She frequency, pelvic mass was noted. A biopsy endometrium revealed poorly differentiated carcinoma. Urinary biopsies showed diagnosed transitional cell to M.D. Anderson Cancer Center (Houston, TX) further treatment recommendations. endometrial both contained carcinomas features. mastectomy specimen invasive ductal significant component. tumor cells from endometrium, were positive cytokeratin (CK) 7 estrogen receptor negative CK20. In view morphologic immunohistochemical profile, interpreted lesions primary. component morphologically identical lung. However, serous has different appearance more akin borderline Immunohistochemical stains useful distinguishing that thyroid transcription factor-1 positivity suggests lung primary, CK7 suggest CK20 It important exclude before making definite primary advanced stage This article discusses differential organs.