Role of MAP kinases in nitric oxide induced muscle-derived adult stem cell apoptosis.
作者： D. Bironaite , D. Baltriukiene , N. Uralova , A. Stulpinas , V. Bukelskiene
DOI: 10.1016/J.CELLBI.2009.03.007
关键词:
摘要: Apoptosis in heart failure has been intensively investigated vitro and vivo. Stem cells have therapeutic value the direct treatment of diseases, including cardiovascular disease. The main drawback stem cell therapy is their poor survival diseased tissues. Since intracellular mitogen-activated protein kinases (MAPKs) actively participate regulation proapoptotic signals, ability to manipulate mechanisms MAPKs activation myogenic might increase transplanted cells. Our results clearly demonstrate sustained all three MAPKs, ERK, JNK p38 after exposure NO inducer, NOC-18. Inhibition phosphorylation by specific inhibitors revealed anti-apoptotic role
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