Phenobarbital removal characteristics of three brands of activated charcoals: a system analysis approach.

摘要: The in vivo phenobarbital removal characteristics of three brands activated charcoal (Actidose, Charcoaid, Superchar) were studied normal volunteers using a system analysis approach. subjects received 200-mg dose oral or intravenous followed by single 30 g one the charcoals randomized crossover design. relative merits enhancing and assessed clearance, time to peak (tp), clearance (Rmax), percentage removed (PCT∞), (CLr) calculated for treatments. Superchar had pulse-like effect, with shortest tp largest Rmax. Actidose Charcoaid similar effects, inducing slightly greater removal. has highest surface area hydroxyl groups, whereas lowest groups studied. Although correlations between vitro adsorption may be difficult due presence preservatives palatibility enhancers commercial preparations, it appears that effectiveness decreases as concentration decrease. proposed approach requires fewer assumptions than methods based on compartmental physiologic approaches advantage describing dynamic manner.