Growth hormone exposure as a risk factor for the development of subsequent neoplasms of the central nervous system: a report from the childhood cancer survivor study.

摘要: Context: Cranial radiation therapy (CRT) predisposes to GH deficiency and subsequent neoplasms (SNs) of the central nervous system (CNS). Increased rates SNs have been reported in GH-treated survivors. Objective: The objective study was evaluate association between treatment development CNS-SNs. Design: designed with a retrospective cohort longitudinal follow-up. Setting: setting multiinstitutional. Participants: A total 12 098 5-year pediatric cancer survivors from Childhood Cancer Survivor Study, diagnosed prior age 21 years, whom 338 self-reported treatment, which verified through medical record review. Interventions: Interventions included subject surveys, records abstraction, pathological Outcome Measures: Incidence meningioma, glioma, other CNS-SNs measured. Results: Among survivors, 16 (4.7%) developed CNS-SN, including 10 meningioma six glio...