Pharmacokinetics of propofol and its conjugates after continuous infusion in normal and in renal failure patients: a preliminary study.

摘要: The pharmacokinetics of propofol, 2,6 diisopropylphenol, were compared in 6 end-stage renal failure patients aged 66.3 +/- 12.1 years and 5 normal 45.5 13.5 years. Anesthesia was induced with propofol (2 2.5 mg.kg-1 respectively) fentanyl (0.1 mg). maintained (9 10 x h-1 respectively). Patients breathed spontaneously a 50 per cent oxygen nitrous oxide mixture. Two ml blood samples taken during anesthesia at regular intervals until up to 24 hours after infusion. Plasma levels determined by HPLC electrochemical detection. Propofol conjugates hydrolysis beta glucuronidase or HCl. Results expressed as median [lower-upper percentiles]. clearance (1.53 [1.02-2.10] L.min-1 kg-1 versus 1.65 [1.39-1.78] patients), half-lives elimination not modified failure. Renal exhibited higher volume distribution steady state (19.28 [11.71-76.81] L.kg-1 8.60 [6.58-9.81] L.kg-1, p < 0.05). did affect the production but they accumulated patients. Despite this, no difference time eyes opening concentration observed, confirming absence clinical effect these metabolites.