Adaptation posologique des médicaments couramment utilisés en réanimation lors d’épuration extrarénale continue

摘要: Drug dosing in the intensive care unit can be challenging. Acute kidney injury (AKI) is a common complication of sepsis and part multiple organ dysfunction syndrome. Continuous renal replacement therapy (CRRT) increasingly used as dialysis this critically ill population. Available data demonstrate that sepsis, AKI different modalities CRRT profoundly change drugs pharmacokinetic. The severity these changes depends on molecules characteristics (volume distribution, plasma protein binding, molecular weight, half-life, clearance), patient itself (volemia, residual function, tissue perfusion, hepatic dysfunction) modality (diffusion, convection, adsorption). There are no available recommendations to adapt drug given with CRRT. It necessary fully understand methods pharmacokinetic prescribe appropriate dose avoid under or potentially toxic overdosing. Monitoring level - when establish relation between blood concentration its effect; thus, facilitating dosing.