Bone Reconstruction with Bone Marrow Stromal Cells

摘要: Abstract Bone marrow stromal/stem cells (BMSCs) are multipotent adult stem and have become the important cell source for therapy engineered tissue repair. Their osteogenic differentiation potential has been well characterized in many vitro studies. In addition, small animal model–based studies also reveal their capability of bone formation vivo when implanted with biodegradable scaffold, indicating great therapeutic application. defect is a common clinical problem that deserves an optimal therapy. Unlike traditional surgical repair needs to sacrifice donor site tissue, tissue‐engineering approach can achieve goal regeneration without necessity morbidity. To safely translate experimental study into trial repair, using large models key issue. Our this aspect published results indicate by BMSCs scaffold realistic be achieved.