Segmental mandibular bone reconstruction with a carbonate-substituted hydroxyapatite-coated modular endoprosthetic poly(ɛ-caprolactone) scaffold in Macaca fascicularis

摘要: A bio-degradable scaffold incorporating osteoinductive factors is one of the alternative methods for achieving regeneration a mandibular bone defect. The current pilot study addressed such reconstruction in non-human primate model, Macaca fascicularis monkeys, with an engineered poly(ɛ-caprolactone) (PCL) scaffold, provided carbonate-substituted hydroxyapatite coating. scaffolds were implanted into unilaterally created segmental defects 24 monkeys. Three experimental groups formed: (1) rhBMP-2 (n = 8), (2) autologous mixed marrow cells and (3) empty as control group 8). Evaluation was based on clinical observation well micro-CT, mechanical, histological analyses. Despite high infection rate, overall results showed that currently designed PCL had insufficient load-bearing capability, complete union not achieved after 6 months implantation. Nevertheless, loaded evidence bone-regenerative potential, contrast to group. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 962–976, 2014.