Development of a biointegrated mandibular reconstruction device consisting of bone compatible titanium fiber mesh scaffold

摘要: Coating biomaterials with a thin hydroxyapatite (HA) was proven effective in enhancing bone compatibility. Segmental defects are considered as the most difficult defect to repair regeneration therapy. We developed submicron-thin HA-coated titanium fiber mesh scaffolds reconstruct immediately loaded segmental mandibular and evaluated their compatibility vitro vivo. Human osteoblasts attachment, proliferation, osteocalcin expression non- were evaluated. A 10-mm long rabbit reconstructed or scaffolds, which removed at 9 21 weeks, evaluate mechanical strength of bone-scaffold connection formation around scaffold. Expression greater scaffolds. In vivo than that non-coated weeks. Newly formed mostly restored continuity. Scanning electron microscopy identified strong integration The 3-fold These results suggest scaffold is bone-compatible reconstruction device defects.