Natural variation in immune responsiveness, with special reference to immunodeficiency and promoter polymorphism in class II MHC genes.
作者： Nicholas A Mitchison , Brigitte Muller , Richard M Segal
DOI: 10.1016/S0198-8859(99)00141-X
关键词:
摘要: This review deals with natural selection operating on heterozygotes as a key factor controlling (a) the frequency of immunodeficiencies, and (b) promoter polymorphism in MHC class II genes. The known difference distribution X-linked autosomal deficiencies lend support to this possibility, suggest that neonatal defect may rise old-established equlibria between entry exit deleterious mutations change. gene promoters differ their capacity favor Th1 (or reciprocally Th2) responses, thus suggesting is sustained by greater flexibility response confers heterozygotes.
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