Erythropoietin response to hypoxia in patients with diabetic autonomic neuropathy and non-diabetic chronic renal failure.

摘要: Aims An erythropoietin (EPO)-deficient anaemia is recognized in Type 1 diabetic patients with early nephropathy and symptomatic autonomic neuropathy (DN). The aim of this study was to determine whether the EPO response hypoxia deficient order clarify mechanisms involved process. Methods Five DN (age 39 (28–48) years (mean (range))) EPO-deficient (haemoglobin, Hb 10.6 (9.5–12.0) g/dl, 5.0 (3.2–6.5) IU/l) (persistent proteinuria 1161.6 (130–2835) mg/day, serum creatinine 97.6 (63–123) µmol/l)) were compared nine normal subjects 31 (24–39) years, 13.4 (11.8–15.7) g/dl, 7.6 (5.6–10.3) IU/l) four non-diabetic advanced chronic renal failure RF (proteinuria 2157.5 (571–4578) mg/day, 490.2 (406–659) µmol/l, 10.3 (9.0–11.3) g/dl, 4.6 (2.9–8.5) IU/l). exposed 6 h (inspired oxygen 11.6–12.6%) by breathing a gas mixture via hood. Hourly levels measured. Results All groups showed rise production after 2 h. group achieved similar maximal at (EPO 17.3 ± 5.4 vs. 17.8 ± 7.9 IU/l). mounted an but lower levels. Conclusions Although have inappropriately low for severity their anaemia, they can mount appropriate moderate hypoxia. mechanism underlying present some remains unclear.