Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type III in Japanese population.
作者： Kozo Hashimoto , Hiroshi Maruyama , Mitsuru Nishiyama , Koichi Asaba , Yukio Ikeda
DOI: 10.1159/000089293
关键词:
摘要: Background: It has been reported that HLA class II haplotypes DRB1*0405-DQA1*0303-DQB1*0401 and DRB1*0901-DQA1*0302-DQB1*0303 are major susceptibility for type 1 diabetes mellitus (DM) in Japanese population. However, little on the patients with autoimmune polyglandular syndrome III (APS III). Patients Methods: of DRB1-DQA1-DQB1 31 APS III, 14 Hashimoto’s thyroiditis alone, 15 Graves’ disease alone were examined divided into three groups (A, B, C) depending combination endocrine diseases. Results: In 13 both DM (group A), haplotype frequencies DRB1*0802-DQA1*0401-DQB1*0402 significantly higher than controls. frequency was controls, whereas did not differ from those 11 B), DRB1*0802-DQA1*0301-DQB1*0302 DRB1*0803-DQA1*0103-DQB1*0601 suggesting group B differed alone. 7 thyroid diseases pituitary disorders C), Conclusions: Susceptible between Caucasian populations. More interestingly, susceptible among types merely a each disease.
sci-hub.se 参考文章(31)
Mitsuo Hashimoto, Tomoko Kinoshita, Miho Yamasaki, Hidenori Tanaka, Tadashi Imanishi, Hideari Ihara, Yasuji Ichikawa, Takanobu Fukunishi, Gene frequencies and haplotypic associations within the HLA region in 916 unrelated Japanese individuals Tissue Antigens. ,vol. 44, pp. 166- 173 ,(1994) , 10.1111/J.1399-0039.1994.TB02375.X
THOMAS HEIBERG BRIX, KIRSTEN OHM KYVIK, LASZLO HEGEDÜS, What is the Evidence of Genetic Factors in the Etiology of Graves' Disease? A Brief Review Thyroid. ,vol. 8, pp. 627- 634 ,(1998) , 10.1089/THY.1998.8.627
T Yanagawa, A Mangklabruks, Y B Chang, Y Okamoto, M E Fisfalen, P G Curran, L J DeGroot, Human histocompatibility leukocyte antigen-DQA1*0501 allele associated with genetic susceptibility to Graves' disease in a Caucasian population. The Journal of Clinical Endocrinology and Metabolism. ,vol. 76, pp. 1569- 1574 ,(1993) , 10.1210/JCEM.76.6.8501164
H. Wallaschofski, A. Meyer, U. Tuschy, T. Lohmann, HLA-DQA1*0301-associated susceptibility for autoimmune polyglandular syndrome type II and III. Hormone and Metabolic Research. ,vol. 35, pp. 120- 124 ,(2003) , 10.1055/S-2003-39059
Pekka Ahonen, Autoimmune polyendocrinopathy--candidosis--ectodermal dystrophy (APECED): autosomal recessive inheritance. Clinical Genetics. ,vol. 27, pp. 535- 542 ,(2008) , 10.1111/J.1399-0004.1985.TB02037.X
Michel Neufeld, Noel MacLaren, Robert Blizzard, Autoimmune polyglandular syndromes. Pediatric Annals. ,vol. 9, pp. 154- 162 ,(1980) , 10.3928/0090-4481-19800401-07
Kentaro Nagamine, Pärt Peterson, Hamish S. Scott, Jun Kudoh, Shinsei Minoshima, Maarit Heino, Kai J. E. Krohn, Maria D. Lalioti, Primus E. Mullis, Stylianos E. Antonarakis, Kazuhiko Kawasaki, Shuichi Asakawa, Fumiaki Ito, Nobuyoshi Shimizu, Positional cloning of the APECED gene Nature Genetics. ,vol. 17, pp. 393- 398 ,(1997) , 10.1038/NG1297-393
T Yanagawa, A Mangklabruks, L J DeGroot, Strong Association between HLA=DQA1*0501 and Graves' Disease in a Male Caucasian Population* The Journal of Clinical Endocrinology and Metabolism. ,vol. 79, pp. 227- 229 ,(1994) , 10.1210/JCEM.79.1.8027232
K. Kotsa, P. F. Watson, A. P. Weetman, A CTLA-4 gene polymorphism is associated with both Graves disease and autoimmune hypothyroidism Clinical Endocrinology. ,vol. 46, pp. 551- 554 ,(1997) , 10.1046/J.1365-2265.1997.1710996.X
D. Czachurski, S. Scherer, S. Gehrke, G. Laux, G. Opelz, J. Mytilineos, Identification of two new HLA alleles: B*3546* and B*5611*. How reliable are the published HLA-B intron 2 sequences? Tissue Antigens. ,vol. 64, pp. 500- 505 ,(2004) , 10.1111/J.1399-0039.2004.00294.X