Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD2 pathway

作者: Pengyun Li , Xingmin Wang , Ming Zhao , Rui Song , Ke-seng Zhao

DOI: 10.1517/14728222.2015.1054806

关键词:

摘要: Objective: The aim of the study was to determine whether hepatocyte mitochondrial injury instigates severe shock and to explore effective therapy. Methods: Wistar rats were randomly …

参考文章(39)
Martin Reers, Stephen T. Smiley, Cristina Mottola-Hartshorn, Ann Chen, Mei Lin, Lan Bo Chen, Mitochondrial membrane potential monitored by JC-1 dye. Methods in Enzymology. ,vol. 260, pp. 406- 417 ,(1995) , 10.1016/0076-6879(95)60154-6
Bixi Jian, Shaolong Yang, Irshad H. Chaudry, Raghavan Raju, Resveratrol Restores Sirtuin 1 (SIRT1) Activity and Pyruvate Dehydrogenase Kinase 1 (PDK1) Expression after Hemorrhagic Injury in a Rat Model Molecular Medicine. ,vol. 20, pp. 10- 16 ,(2014) , 10.2119/MOLMED.2013.00077
Runzhi Zhu, Yajing Wang, Liangqing Zhang, Qinglong Guo, Oxidative stress and liver disease Hepatology Research. ,vol. 42, pp. 741- 749 ,(2012) , 10.1111/J.1872-034X.2012.00996.X
Xingmin Wang, Rui Song, Yunyan Chen, Ming Zhao, Ke-seng Zhao, Polydatin – a new mitochondria protector for acute severe hemorrhagic shock treatment Expert Opinion on Investigational Drugs. ,vol. 22, pp. 169- 179 ,(2013) , 10.1517/13543784.2013.748033
Doraid Jarrar, Ping Wang, William G. Cioffi, Kirby I. Bland, and Irshad H. Chaudry, Critical Role of Oxygen Radicals in the Initiation of Hepatic Depression after Trauma Hemorrhage Journal of Trauma-injury Infection and Critical Care. ,vol. 49, pp. 879- 885 ,(2000) , 10.1097/00005373-200011000-00015
Xingmin Wang, Rui Song, Hui Ning Bian, Ulf T. Brunk, Ming Zhao, Ke-seng Zhao, Polydatin, a natural polyphenol, protects arterial smooth muscle cells against mitochondrial dysfunction and lysosomal destabilization following hemorrhagic shock. American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 302, ,(2012) , 10.1152/AJPREGU.00350.2011
S Rose, A Pizanis, M Silomon, Altered hepatocellular Ca2+ regulation during hemorrhagic shock and resuscitation Hepatology. ,vol. 25, pp. 379- 384 ,(1997) , 10.1002/HEP.510250220
Shin-ichiro Imai, Leonard Guarente, NAD+ and sirtuins in aging and disease Trends in Cell Biology. ,vol. 24, pp. 464- 471 ,(2014) , 10.1016/J.TCB.2014.04.002
Andrew P. Halestrap, Andrew P. Richardson, The mitochondrial permeability transition: A current perspective on its identity and role in ischaemia/reperfusion injury Journal of Molecular and Cellular Cardiology. ,vol. 78, pp. 129- 141 ,(2015) , 10.1016/J.YJMCC.2014.08.018
Kelly M. Quesnelle, Phillip V. Bystrom, Luis H. Toledo-Pereyra, Molecular responses to ischemia and reperfusion in the liver Archives of Toxicology. ,vol. 89, pp. 651- 657 ,(2015) , 10.1007/S00204-014-1437-X