Enzymatic kinetic resolution of racemic ketones catalyzed by Baeyer-Villiger monooxygenases
作者： Cristina Rodríguez , Gonzalo de Gonzalo , Marco W. Fraaije , Vicente Gotor
DOI: 10.1016/J.TETASY.2007.05.033
关键词:
摘要: Abstract A set of racemic cyclic and linear ketones, as well 2-phenylpropionaldehyde, were tested substrates in the enzymatic Baeyer–Villiger oxidation catalyzed by two monooxygenases: phenylacetone monooxygenase (PAMO) 4-hydroxyacetophenone (HAPMO). Excellent enantioselectivites (E > 200) can be obtained kinetic resolution processes depending on substrate structure reaction conditions. The parameters affecting biocatalytic properties these enzymes also studied, order to establish a deeper understanding novel biocatalysts.
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