Circulating Inflammatory Cytokines and Adipokines Are Associated With Increased Risk of Barrett's Esophagus: A Case–Control Study

摘要: Background & Aims Obesity is associated with Barrett's esophagus (BE) and changes in circulating levels of adipokines (leptin adiponectin) cytokines. Although studies have reported that inflammatory cytokines are necessary for the development BE, their role controversial. Methods We performed a case–control study; cases (n = 141) were patients who underwent esophagogastroduodenoscopy found to which was based on endoscopy histology, controls 139) primary care eligible screening colonoscopies agreed undergo esophagogastroduodenoscopy. examined association between BE (interleukin [IL]-1β, IL-6, IL-8, IL-10, IL-12p70; tumor necrosis factor-α; interferon-γ). Cases compared by calculating odds ratios (ORs) 95% confidence intervals (CIs) using unadjusted multiple logistic regression, adjusting age, sex, race, waist-hip ratio, use proton pump inhibitors nonsteroidal anti-inflammatory drugs, Helicobacter pylori infection. Results The adjusted ORs 2.62 (95% CI, 1.0–6.8), 5.18 1.7–15.7), 8.02 2.79–23.07) highest quintile vs lowest IL-12p70, leptin, respectively, but OR not significant IL-6 (2.39; 0.84–6.79). 0.14 IL-10 0.05–0.35) 0.03 IL-1β ≥ median none detected 0.006–0.13). Higher IL-8 leptin lower presence long-segment (≥3 cm) short-segment BE. There no differences interferon-γ, factor-α, adiponectin, or insulin. Conclusions low These findings could partly explain effect obesity