TRAF2 plays a dual role in NF-κB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IκB kinase pathways
作者： Isabelle Carpentier , Wim Declercq , Nikolai L Malinin , David Wallach , Walter Fiers
DOI: 10.1016/S0014-5793(98)00226-9
关键词:
摘要: We previously demonstrated that p38 MAPK is a crucial mediator in the NF-kappaB-dependent gene activation induced by TNF. Here, we have studied role of several TNF receptor-associated proteins and caspases The latter appears to be dependent on TRAF2, but independent FADD or caspases. Remarkably, proceeds independently TRAF2-associated NF-kappaB-inducing kinase NIK, which known bind activate two recently identified IkappaB kinases. These results demonstrate pathways involved NF-kappaB regulation, viz. NIK MAPK-mediated, diverge at level TRAF2.
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