Hydrocephalus in mice following X-irradiation at early gestational stage: possibly due to persistent deceleration of cell proliferation.

摘要: Brain abnormality/ Hydrocephalus/ Cell proliferation/ Early gestational stage/ Persistent effects The pathogenesis of X-ray-induced congenital hydrocephalus was studied. Pregnant mice were irradiated at 1.4 Gy on day 7 (G7). Four hours after irradiation, extensive cell death evident in the neuroepithelium and underlying mesoderm head region, proliferating nuclear antigen (PCNA)-immunoreactive cells almost disappeared. Embryos with thinner lamina terminalis telencephalon, when compared that control, found group G9. As early as G11 some embryos telencephalic wall lateral ventricles larger than those control. choroid invagination from began control brain, but not affected brain. During following development, fetuses readily apparent consistently among fetuses. In these brains brain mantle thinner, corpus striatum thalamic regions smaller, Even G13 frequencies PCNA-positive other lower hydrocephalic suggesting a decelerated proliferation successive generations exposure to X-rays. cerebral aqueduct open during fetal period dilated. vaulted birth completely occluded even animals. These findings suggested followed by persistent deceleration neural proliferation, resulting hypoplasia parenchyma compensatory ventricular dilatation, is important for establishment hydrocephalus.