Anal dysplasia in homosexual men: role of anoscopy and biopsy.
作者： Christina M. Surawicz , Philip Kirby , Cathy Critchlow , James Sayer , Carol Dunphy
DOI: 10.1016/0016-5085(93)90880-L
关键词:
摘要: Abstract Background: Both anal squamous cell cancer and human papilloma virus (HPV) are increased in homosexual men. This study evaluates histology of internal abnormalities a high-risk population immunodeficiency (HIV) seropositive seronegative Methods: Ninety men with the canal (referred from crosssectional 512 men) were evaluated by anoscopy, cytology, directed biopsy. CD4 counts blood HPV types tissue also obtained. Results: Seventy-eight (86%) had HPV-associated abnormalities: discrete warts 39 (43%), wart ring 23 (26%), flat white epithelium 18 (20%). Dysplasia was detected cytology 36% biopsy 92% (27% high grade). High-grade dysplasia equally common HIV-seropositive -seronegative The morphology lesions did not predict presence dysplasia. high- low-risk many specimens. Conclusions: Anal is specimens visible abnormalities. Natural history studies needed to determine clinical significance dysplasia, rates progression cancer, role screening therapy.
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