Anal neoplasia. Pathogenesis, diagnosis, and management.

摘要: There is a clear association between immunodeficiency and the development of various forms neoplasia. Non-Hodgkin's lymphoma common occurrence in congenital states such as Wiskott-Aldrich syndrome, variable immunodeficiency, ataxia-telangiectasia. Organ transplant recipients treated with immunosuppressive therapies to prevent graft rejection are at high risk for non-Hodgkin's lymphoma, Kaposi's sarcoma, anal cervical malignancies. sarcoma also occur unusual frequency persons caused by infection human virus (HIV). Recently, numerous observations have suggested that HIV-induced may be associated neoplasia mucosa. Cervical intraepithelial (dysplasia, squamous lesion) detectable papillomavirus (HPV) been shown more intractable HIV-infected women then non–HIV-infected similar demographic characteristics. Invasive cancer appears aggressive disease, less likely successfully standard therapies, it consequently poorer prognosis than comparable women. Similarly, HPV severe men persons. Anecdotal suggest difficult treat non–HIV-infected. Anal therefore become cause serious morbidity HIV disease patients profound who would succumbed opportunistic infections earlier epidemic, survive extended periods because increasingly effective antiretroviral, prophylactic, antimicrobial therapies. The resulting state prolonged, provides necessary milieu emergence diseases, carcinoma, develop after relatively longer latency. This article reviews current knowledge regarding role pathogenesis considers epidemiologic clinical aspects infection. Finally, strategies diagnosis treatment will discussed.