Analysis of the immune response and viral evolution during the acute phase of SIV infection.
作者： Helen Horton , Thorsten Vogel , David O’Connor , Louis Picker , David I Watkins
DOI: 10.1016/S0264-410X(02)00069-5
关键词:
摘要: Development of an effective vaccine against human immunodeficiency virus (HIV) will require knowledge the immune responses that correlate with protection. During acute phase HIV infection host appear to control viral replication. It is thought virus-specific cellular immunity intimately involved in this control. We have developed a model system measure entire T cell response and evolution face onslaught rhesus macaques during molecularly cloned simian (SIV). used intracellular cytokine staining (ICS) peripheral blood mononuclear cells (PBMCs) from animals stimulated peptides spanning protein sequence SIV determine which were recognized by CD8 CD4 positive cells. Furthermore, we sequenced infection. This approach has proved highly for measuring SIV-infected might facilitate definition HIV-infected humans phase.
elsevier.com
sci-hub.se 参考文章(20)
Norval W. King, Laura V. Chalifoux, Douglas J. Ringler, Michael S. Wyand, Prabhat K. Sehgal, Muthiah D. Daniel, Norman L. Letvin, Ronald C. Desrosiers, Beverly J. Blake, Ronald D. Hunt, Comparative biology of natural and experimental SIVmac infection in macaque monkeys: a review. Journal of Medical Primatology. ,vol. 19, pp. 109- 118 ,(1990) , 10.1111/J.1600-0684.1990.TB00418.X
D. I. Watkins, MHC of Nonhuman Primates Current Topics in Microbiology and Immunology. ,vol. 188, pp. 145- 159 ,(1994) , 10.1007/978-3-642-78536-8_8
R. E. Bontrop, J. S. Lanchbury, E. E. M. Jaeger, Nucleotide sequences, polymorphism and gene deletion of T cell receptor beta-chain constant regions of Pan troglodytes and Macaca mulatta. Journal of Immunology. ,vol. 151, pp. 5301- 5309 ,(1993)
Y Yasutomi, K A Reimann, C I Lord, M D Miller, N L Letvin, Simian immunodeficiency virus-specific CD8+ lymphocyte response in acutely infected rhesus monkeys. Journal of Virology. ,vol. 67, pp. 1707- 1711 ,(1993) , 10.1128/JVI.67.3.1707-1711.1993
Christine J. Pitcher, Claudia Quittner, Dolores M. Peterson, Mark Connors, Richard A. Koup, Vernon C. Maino, Louis J. Picker, HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression. Nature Medicine. ,vol. 5, pp. 518- 525 ,(1999) , 10.1038/8400
Myles R. Allen, Peter A. Stott, John F. B. Mitchell, Reiner Schnur, Thomas L. Delworth, Quantifying the uncertainty in forecasts of anthropogenic climate change Nature. ,vol. 407, pp. 617- 620 ,(2000) , 10.1038/35036559
Todd M. Allen, David H. O'Connor, Peicheng Jing, John L. Dzuris, Bianca R. Mothé, Thorsten U. Vogel, Ed Dunphy, Max E. Liebl, Carol Emerson, Nancy Wilson, Kevin J. Kunstman, Xiaochi Wang, David B. Allison, Austin L. Hughes, Ronald C. Desrosiers, John D. Altman, Steven M. Wolinsky, Alessandro Sette, David I. Watkins, Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia. Nature. ,vol. 407, pp. 386- 390 ,(2000) , 10.1038/35030124
R A Koup, J T Safrit, Y Cao, C A Andrews, G McLeod, W Borkowsky, C Farthing, D D Ho, Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. Journal of Virology. ,vol. 68, pp. 4650- 4655 ,(1994) , 10.1128/JVI.68.7.4650-4655.1994
Z W Chen, H Yamamoto, D I Watkins, G Levinson, N L Letvin, Predominant use of a T-cell receptor V beta gene family in simian immunodeficiency virus Gag-specific cytotoxic T lymphocytes in a rhesus monkey. Journal of Virology. ,vol. 66, pp. 3913- 3917 ,(1992) , 10.1128/JVI.66.6.3913-3917.1992
M. Daniel, N. Letvin, N. King, M Kannagi, P. Sehgal, R. Hunt, P. Kanki, M Essex, R. Desrosiers, Isolation of T-cell tropic HTLV-III-like retrovirus from macaques Science. ,vol. 228, pp. 1201- 1204 ,(1985) , 10.1126/SCIENCE.3159089