Prevalence and identity of cdt-related sequences in necrotoxigenic Escherichia coli.
作者： Jacques G. Mainil , Etienne Jacquemin , Eric Oswald
DOI: 10.1016/S0378-1135(03)00102-0
关键词:
摘要: The cytolethal distending toxins (CDT) are responsible for the mitosis block at G2/M and cycle arrest of cells in culture. Escherichia coli isolated from humans animals with intestinal extra-intestinal diseases can be positive production a CDT-like cytopathic effect or presence cdt-related genes. purpose this study was to compare prevalence identity sequences necrotoxigenic E. (NTEC). A collection 98 bovine type 2 NTEC (NTEC2) 45 bovine, 20 canine, 3 feline, 65 human 129 porcine 1 (NTEC1) isolates studied by colony hybridisation PCR assays specific cdtB genes encoding B sub-unit CDT-I, CDT-II, CDT-III CDT-IV produced coli. cdtB-III were frequent amongst NTEC2, since 83% these and/or PCR, whereas cdtB-related rare NTEC1, only (4%), canine (15%), 10 (15%) 13 (10%) positive. 28 probe-positive NTEC1 harboured cdtB-IV (13 isolates), cdtB-I (10 still unidentified (5 isolates). After comparison previously published unpublished results phenotypic assay on cell cultures, existence other is suggested NTEC1. differences between NTEC2 their CDT profiles may have implication pathogenesis those two classes pathogenic
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