Somatostatin and octreotide modulate the function of Kupffer cells in liver cirrhosis
作者： Tzu-Chieh Chao , Hsiao-Hsiang Chao , Jen-Der Lin , Miin-Fu Chen
DOI: 10.1016/S0167-0115(98)00150-5
关键词:
摘要: In our previous studies we have shown that somatostatin and octreotide modulate the function of peritoneal macrophages Kupffer cells in noncirrhotic livers. However, effects on cirrhotic livers are not known. present study, cells, obtained from male rats with carbon tetrachloride-induced livers, were treated vitro or their release nitric oxide, tumor necrosis factor-alpha (TNF-alpha) peroxide (H2O2) determined. At concentrations 10(-13) 10(-10) to 10(-6) M 10(-12) M, octreotide, amount oxide released by was significantly suppressed relative untreated cells. less than greater TNF-alpha compared controls. addition, zymosan-induced H2O2 10(-9) 10(-7) 10(-15) These findings demonstrate depending hormones used.
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