摘要: The replisome quickly and accurately copies billions of DNA bases each cell division cycle. However, it can make errors, especially when the template is damaged. In these cases, replication-coupled repair mechanisms remove mistake or lesions to ensure high fidelity complete copying genome. Failures in genome maintenance activities generate mutations, rearrangements, chromosome segregation problems that cause many human diseases. this review, I provide a broad overview pathways, explaining how they fix polymerase mistakes, respond damage acts as obstacles replisome, deal with broken forks, impact health disease.
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sci-hub.se 参考文章(104)
A. Ciccia, A. L. Bredemeyer, M. E. Sowa, M.-E. Terret, P. V. Jallepalli, J. W. Harper, S. J. Elledge, The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart Genes & Development. ,vol. 23, pp. 2415- 2425 ,(2009) , 10.1101/GAD.1832309
Silvana Mourón, Sara Rodriguez-Acebes, María I Martínez-Jiménez, Sara García-Gómez, Sandra Chocrón, Luis Blanco, Juan Méndez, Repriming of DNA synthesis at stalled replication forks by human PrimPol Nature Structural & Molecular Biology. ,vol. 20, pp. 1383- 1389 ,(2013) , 10.1038/NSMB.2719
JoAnn Sekiguchi, Stewart Shuman, Site-Specific Ribonuclease Activity of Eukaryotic DNA Topoisomerase I Molecular Cell. ,vol. 1, pp. 89- 97 ,(1997) , 10.1016/S1097-2765(00)80010-6
Katsuhiro Hanada, Magda Budzowska, Sally L Davies, Ellen van Drunen, Hideo Onizawa, H Berna Beverloo, Alex Maas, Jeroen Essers, Ian D Hickson, Roland Kanaar, The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks Nature Structural & Molecular Biology. ,vol. 14, pp. 1096- 1104 ,(2007) , 10.1038/NSMB1313
José M Sogo, Massimo Lopes, Marco Foiani, Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects Science. ,vol. 297, pp. 599- 602 ,(2002) , 10.1126/SCIENCE.1074023
Jing Huang, Shuo Liu, Marina A. Bellani, Arun Kalliat Thazhathveetil, Chen Ling, Johan P. de Winter, Yinsheng Wang, Weidong Wang, Michael M. Seidman, The DNA translocase FANCM/MHF promotes replication traverse of DNA interstrand crosslinks. Molecular Cell. ,vol. 52, pp. 434- 446 ,(2013) , 10.1016/J.MOLCEL.2013.09.021
Jordan A. St Charles, Sascha E. Liberti, Jessica S. Williams, Scott A. Lujan, Thomas A. Kunkel, Quantifying the contributions of base selectivity, proofreading and mismatch repair to nuclear DNA replication in Saccharomyces cerevisiae DNA Repair. ,vol. 31, pp. 41- 51 ,(2015) , 10.1016/J.DNAREP.2015.04.006
Jieqiong Zhang, James M Dewar, Magda Budzowska, Anna Motnenko, Martin A Cohn, Johannes C Walter, DNA interstrand cross-link repair requires replication-fork convergence. Nature Structural & Molecular Biology. ,vol. 22, pp. 242- 247 ,(2015) , 10.1038/NSMB.2956
Sara García-Gómez, Aurelio Reyes, María I. Martínez-Jiménez, E. Sandra Chocrón, Silvana Mourón, Gloria Terrados, Christopher Powell, Eduardo Salido, Juan Méndez, Ian J. Holt, Luis Blanco, PrimPol, an Archaic Primase/Polymerase Operating in Human Cells Molecular Cell. ,vol. 52, pp. 541- 553 ,(2013) , 10.1016/J.MOLCEL.2013.09.025
Angela Deem, Andrea Keszthelyi, Tiffany Blackgrove, Alexandra Vayl, Barbara Coffey, Ruchi Mathur, Andrei Chabes, Anna Malkova, Break-Induced Replication Is Highly Inaccurate PLoS Biology. ,vol. 9, pp. e1000594- ,(2011) , 10.1371/JOURNAL.PBIO.1000594