Olfactory mucosal findings in patients with persistent anosmia after endoscopic sinus surgery.

摘要: Sixty-three biopsy specimens were obtained from the olfactory region of 15 patients with persistent anosmia and 6 normosmia after sinus surgery. Immunohistochemical examination all microtubule-associated protein 5 (MAP5) antisera demonstrated epithelium in 11 18 normosmic 12 45 samples anosmic patients. There was a significant difference proportion containing between two groups In patients, most contained normal-appearing tissue. However, 2 main patterns histologic findings noted mucosa First, receptor cells remarkably decreased number. Second, orderly arrangement characteristic normal lost, demonstrating degenerative appearance. These data suggest that can be degenerated even chronic sinusitis thereafter extensively replaced respiratory epithelium, resulting increased sampling error. Moreover, an unimproved deficit surgery may due to abnormalities observed at level.