Applications of conformational design: rational design of chiral ligands derived from a common chiral source for highly enantioselective preparations of (R)- and (S)-enantiomers of secondary alcohols

摘要: A pair of diastereomers 7 and 8 were easily synthesized in only two steps from a single common chiral source according to the concept of conformation design. The efficiency of these chiral ligands was evaluated by their application to the asymmetric addition of diethylzinc to aldehydes. This catalytic asymmetric process afforded the a most efficient access to the (R)-and (S)-enantiomers of a given secondary alcohol with similarly outstanding enantioselectivities and high yields. Our results also showed that the control of …