Cervical infections by multiple human papillomavirus (HPV) genotypes: Prevalence and impact on the risk of precancerous epithelial lesions.

摘要: A large proportion of human papillomavirus (HPV) infections is sustained by multiple genotypes. The effect on the risk cervical intraepithelial neoplasia (CIN) and potential efficacy vaccine these are controversial. We performed viral typing SFP10-LIPA a consecutive series 1,323 women undergoing colposcopy, 69% whom had biopsy, correlated CIN severity with type number HPVs. Overall prevalence HPV-DNA was 68.9%, 97.3% in CIN1, 98.1% CIN≥2. HPV positivity younger age (35.9 vs. 37.3 years, P = 0.026) history (P < 0.001). Multiple types were detected 44.2% cases, including 63.1% CIN1 80.8% Twenty-three different detected, HPV-16, 31 52 being most frequent. Infections HPV-6, 11, 16, or 18 occurred 59.4% 71.3% Number class oncogenic linearly (P < 0.0001) univariate multivariate analyses controlling for CIN. maintained after exclusion from model 18. Frequency, distribution, clinical correlates highlight importance assessing individual management prediction outcome abnormal baseline cytology point to limitations current strategies. J. Med. Virol. 81:703–712, 2009 © Wiley-Liss, Inc.