Transitions in immune responses to Mycobacterium paratuberculosis

作者: J Stabel

DOI: 10.1016/S0378-1135(00)00331-X

关键词:

摘要: The host immune response to infection with Mycobacterium paratuberculosis is paradoxical, strong cell-mediated responses during the early, subclinical stages of and humoral late clinical disease. Cell-mediated modulated by various T cell subsets are essential provide protective immunity prevent progression Secretion cytokines populations serves activate macrophages kill ingested M. as well other contain infection. This paper reviews current knowledge in based upon studies research using mouse models.

参考文章(47)
S. B. Linda, J. R. Simpson, R. K. Braun, C. D. Buergelt, R. C. Littell, Use of an enzyme-linked immunosorbent assay to estimate prevalence of paratuberculosis in cattle of Florida. Javma-journal of The American Veterinary Medical Association. ,vol. 196, pp. 1251- 1254 ,(1990)
Stanley Cohen, Lymphokines and the immune response CRC Press. ,(1990)
G. R. Snyder, J. M. Sacks, R. S. Merkal, D. L. Whipple, Prevalence of Mycobacterium paratuberculosis in ileocecal lymph nodes of cattle culled in the United States. Javma-journal of The American Veterinary Medical Association. ,vol. 190, pp. 676- 680 ,(1987)
J C Cerottini, H R MacDonald, J W Lowenthal, Interleukin 1-dependent induction of both interleukin 2 secretion and interleukin 2 receptor expression by thymoma cells. Journal of Immunology. ,vol. 137, pp. 1226- 1231 ,(1986)
R. J. Chiodini, R. S. Merkal, H. J. van Kruiningen, Ruminant paratuberculosis (Johne's disease): the current status and future prospects. The Cornell veterinarian. ,vol. 74, pp. 218- 262 ,(1984)
David A. Ferrick, Mark D. Schrenzel, Thera Mulvania, Beryl Hsieh, Walter G. Ferlin, Heather Lepper, Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo Nature. ,vol. 373, pp. 255- 257 ,(1995) , 10.1038/373255A0
Robert L Coffman, Timothy R Mosmann, Martin A Giedlin, Holly Cherwinski, Martha W Bond, Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. Journal of Immunology. ,vol. 136, pp. 2348- 2357 ,(1986)