Thalamic atrophy and cognition in multiple sclerosis

摘要: Objectives: Recent studies have indicated that brain atrophy is more closely associated with cognitive impairment in multiple sclerosis (MS) than are conventional MRI lesion measures. Enlargement of the third ventricle shows a particularly strong correlation impairment, suggesting clinical relevance damage to surrounding structures, such as thalamus. Previous imaging and pathology demonstrated thalamic involvement MS. In this study, we tested hypothesis volume lower MS normal subjects, correlates function. Methods: We studied 79 patients 16 subjects. A subgroup 31 subjects underwent testing. The thalamus was segmented whole from three-dimensional scans. also determined (brain parenchymal fraction), ventricular width, T2-weighted (fluid-attenuated inversion recovery) hyperintense, T1 hypointense, gadolinium-enhanced volumes. Results: Normalized 16.8% group ( p r = 0.506 0.724, −0.316, 0.005). Conclusion: These findings suggest clinically relevant biomarker neurodegenerative disease process sclerosis.