Morphology-Variable Aggregates Prepared from Cholesterol-Containing Amphiphilic Glycopolymers: Their Protein Recognition/Adsorption and Drug Delivery Applications.
作者： Zhao Wang , Ting Luo , Amin Cao , Jingjing Sun , Lin Jia
DOI: 10.3390/NANO8030136
关键词:
摘要: In this study, a series of diblock glycopolymers, poly(6-O-methacryloyl-d-galactopyranose)-b-poly(6-cholesteryloxyhexyl methacrylate) (PMAgala-b-PMAChols), with cholesterol/galactose grafts were prepared through sequential reversible addition-fragmentation chain transfer (RAFT) polymerization and deprotection process. The glycopolymers could self-assemble into aggregates various morphologies depending on cholesterol/galactose-containing block weight ratios, as determined by transmission electronic microscopy (TEM) dynamic laser light scattering (DLS). addition, the lectin (Ricinus communis agglutinin II, RCA120) recognition bovine serum albumin (BSA) adsorption PMAgala-b-PMAChol evaluated. SK-Hep-1 tumor cell inhibition properties PMAgala-b-PMAChol/doxorubicin (DOX) complex further examined in vitro. Results indicate that showed different interaction/recognition features RCA120 BSA. Spherical (d ≈ 92 nm) possessed highest ability lowest BSA protein adsorption. DOX-loaded spherical exhibited better property than those nanofibrous aggregates. morphology-variable derived from amphiphilic may serve multifunctional biomaterials biomolecular drug delivery features.
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Xiaoqian Shan, Changsheng Liu, Fengqian Li, Chunfa Ouyang, Qun Gao, Kangsheng Zheng, Nanoparticles vs. nanofibers: a comparison of two drug delivery systems on assessing drug release performance in vitro Designed Monomers and Polymers. ,vol. 18, pp. 678- 689 ,(2015) , 10.1080/15685551.2015.1070500
Mark J. Bowick, Daniel Lévy, Amin Cao, Min Hui Li, Lin Jia, Xiangjun Xing, Bing Xu, Pierre Antoine Albouy, Smectic polymer vesicles Soft Matter. ,vol. 5, pp. 3446- 3451 ,(2009) , 10.1039/B907485F
Yaling Liu, Jifu Tan, Antony Thomas, Daniel Ou-Yang, Vladimir R Muzykantov, The shape of things to come: importance of design in nanotechnology for drug delivery Therapeutic Delivery. ,vol. 3, pp. 181- 194 ,(2012) , 10.4155/TDE.11.156
L. Zhang, K. Yu, A. Eisenberg, Ion-Induced Morphological Changes in “Crew-Cut” Aggregates of Amphiphilic Block Copolymers Science. ,vol. 272, pp. 1777- 1779 ,(1996) , 10.1126/SCIENCE.272.5269.1777
Byung-Sun Kim, Dong-Je Hong, Jinyoung Bae, Myongsoo Lee, Controlled self-assembly of carbohydrate conjugate rod-coil amphiphiles for supramolecular multivalent ligands. Journal of the American Chemical Society. ,vol. 127, pp. 16333- 16337 ,(2005) , 10.1021/JA055999A
Jing-Yi Zhu, Qi Lei, Bin Yang, Hui-Zhen Jia, Wen-Xiu Qiu, Xuli Wang, Xuan Zeng, Ren-Xi Zhuo, Jun Feng, Xian-Zheng Zhang, Efficient nuclear drug translocation and improved drug efficacy mediated by acidity-responsive boronate-linked dextran/cholesterol nanoassembly. Biomaterials. ,vol. 52, pp. 281- 290 ,(2015) , 10.1016/J.BIOMATERIALS.2015.02.048
Irene C. Reynhout, Jeroen J. L. M. Cornelissen, Roeland J. M. Nolte, Synthesis of polymer-biohybrids: from small to giant surfactants. Accounts of Chemical Research. ,vol. 42, pp. 681- 692 ,(2009) , 10.1021/AR800143A
Jiawei Lu, Changkui Fu, Shiqi Wang, Lei Tao, Litang Yan, David M. Haddleton, Gaojian Chen, Yen Wei, From Polymer Sequence Control to Protein Recognition: Synthesis, Self-Assembly and Lectin Binding Macromolecules. ,vol. 47, pp. 4676- 4683 ,(2014) , 10.1021/MA500664U
Sema Sevimli, Fatih Inci, Hadi M. Zareie, Volga Bulmus, Well-defined cholesterol polymers with pH-controlled membrane switching activity. Biomacromolecules. ,vol. 13, pp. 3064- 3075 ,(2012) , 10.1021/BM300846E
John-Michael Williford, Jose Luis Santos, Rishab Shyam, Hai-Quan Mao, Shape control in engineering of polymeric nanoparticles for therapeutic delivery Biomaterials Science. ,vol. 3, pp. 894- 907 ,(2015) , 10.1039/C5BM00006H