Luteinizing hormone: Evidence for direct action in the CNS

摘要: This article is part of a Special Issue "SBN 2014". Hormonal dysfunction due to aging, especially during menopause, plays substantial role in cognitive decline as well the progression and development neurodegenerative diseases. The hypothalamic-pituitary-gonadal (HPG) axis has long been implicated changes behavior neuronal morphology. Most notably, estrogens have proven beneficial healthy brain through host different mechanisms. Recently, luteinizing hormone (LH) emerged candidate for further investigation its CNS. basis this that both LH receptor are expressed brain, serum levels correlate with deficits Alzheimer's disease (AD) incidence. study cognition AD primarily focuses on evaluating effects downregulation peptide. literature shown decreasing peripheral LH, variety pharmacological interventions, reduces ovariectomy models. However, few studies researched direct actions neurons glial cells. Here we summarize modulating cognition, propose mechanism underlies process.