Menstrual cycle irregularity and menopause status influence cognition in women with schizophrenia

摘要: Cognitive impairments are a core feature of schizophrenia and contribute significantly to functional complications. Current pharmacological treatments do not ameliorate cognitive dysfunction the aetiology poorly understood. Hormones hypothalamic-pituitary-gonadal (HPG) axis that regulate reproductive function have multiple effects on development, maintenance brain been suggested also influence cognition. The aim current study was investigate how HPG hormones effect cognition, specifically exploring menopause status menstrual cycle irregularity performance in women with schizophrenia. data for present represents pooled baseline from three clinical trials. Two hundred forty female participants diagnosis or schizoaffective disorder were included analysis. Cognition assessed using Repeatable Battery Assessment Neuropsychological Status. Hormone assays serum sex steroids pituitary (including estradiol, progesterone, luteinising hormone follicle-stimulating hormone) conducted classified as postmenopausal; perimenopausal; premenopausal/reproductive, further into regular irregular cycles. To model comparison i) ii) post-menopausal iii) aged cycles semiparametric regression (generalised additive mode) fitted. results revealed females schizophrenia, predicted poorer areas psychomotor speed, verbal fluency memory. Perimenopause associated changes period visuospatial performance. This provides evidence associate