Therapy of mouse lymphoma with monoclonal antibodies to glycolipid: selection of low antigenic variants in vivo
作者： W. Young , S. Hakomori
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摘要: Growth of mouse lymphoma L5178Y, which contains large quantitites the gangliotriosylceramide (GgOs3Cer), in DBA/2 mice was suppressed by passive immunization with monoclonal immunoglobulin G3 antibodies to GgOS3Cer, but not M or without added complement. Most groups treated did develop tumors, tumor that appeared a animal had much lower amount GgOS3Cer than cells used for inoculation. Thus, either prevented growth caused selection variant quantity antigen GgOS3Cer.
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